Volume: 1, 2022
1st International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: A019
DOI: https://doi.org/10.24326/ICDSUPL1.A019
Published online: 26 April 2022
ICDSUPL, 1, A019 (2022)
Organoselenium compounds activity against Trichophyton mentagrophytes human origin isolates
Dominik Łagowski1*, Sebastian Gnat1, Mariusz Dyląg2, Marcelina Osińska1, Aleksandra Trościańczyk1, Aneta Nowakiewicz1
1 Faculty of Veterinary Medicine, Department of Veterinary Microbiology, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland
2 Faculty of Biological Sciences, Department of Mycology and Genetics, University of Wroclaw, Uniwersytecki Sq. 1, 50-137 Wrocław, Poland
* Corresponding author: dominik.lagowski@up.lublin.pl
Abstract
Dermatophytoses are one of the most prevalent infectious diseases in the world for which the pace of developing new drugs has not kept pace with the observed therapeutic problems. Thus, searching for new antifungals with alternative and novel mechanism of action is necessary. Objective: This study aimed to evaluate the antifungal activity of ebselen and diphenyl diselenide against Trichophyton mentagrophytes clinical isolates. Methods: In vitro antifungal susceptibility was assessed for organoselenium compounds used alone or in combination with allylamines and azoles according to the 3rd edition of the CLSI M38 protocol. Results: Ebselen demonstrated high antifungal activity with MICGM equal to 0.442 μg/ml in the case of human origin strains. The values of MICGM of diphenyl diselenide were higher: 17.36 μg/ml for the tested isolates. Synergistic or additive effects between terbinafine and ebselen or diphenyl diselenide were observed in the case of 18% and 23,5% strains, respectively. In turn, the combination of itraconazole with diphenyl diselenide showed a synergistic effect only in the case of 12% of the tested strains, whereas no synergism was shown in the combination with ebselen. Conclusions: The results highlight the promising activity of organoselenium compounds against Trichophyton mentagrophytes. However, their use in combinational therapy with antifungal drugs seems to be unjustified due to the weak synergistic effect observed.
How to cite
D. Łagowski, S. Gnat, M. Dyląg, M. Osińska, A. Trościańczyk, A. Nowakiewicz, 2022. Organoselenium compounds activity against Trichophyton mentagrophytes human origin isolates. In: 1st International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL1/A019