Volume: 2, 2023
2nd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: A029
DOI: https://doi.org/10.24326/ICDSUPL2.A029
Published online: 19 April 2023
ICDSUPL, 2, A029 (2023)
Effect of feeding diet containing coccidiostat and administration of antibiotics to turkeys in the first days after hatching on blood inflammatory indicators
Łukasz Szymański1*, Radosław Smagieł2, Ewelina Cholewińska2, Katarzyna Ognik2, Krzysztof Kozłowski1, Jan Jankowski1
1 Department of Poultry Science and Apiculture, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland
2 Department of Biochemistry and Toxicology, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
* Corresponding author: lukasz.szymanski@uwm.edu.pl
Abstract
The aim of the study was to determine the effect of early administration of an antibiotic, especially when fed a diet containing a coccidiostat, on the level of pro-inflammatory markers. The experiment was conducted on 1152 one-day-old turkeys divided into 6 treatments: CM(-), EM(-), DM(-), CM(+), EM(+), DM(+). Turkeys in the M(-) groups did not receive monensin in the diet, while those in the M(+) groups received monensin at a dose of 90 mg/kg of feed. Turkeys in groups C, received no antibiotic supplement (control groups), while those in groups E received enrofloxacin at a dose of 10 mg/kg BW for the first 5 days of life, and those in groups D received doxycycline at a dose of 50 mg/kg BW for the first 5 days of life. The birds were vaccinated against APV and NDV on day 1 of life and against ORT on day 28 of life. On days 7 and 56, blood was collected from 8 birds in the group to evaluate monensin, enrofloxacin, and doxycycline levels. On days 7 and 56, blood was collected from 8 birds in the group to evaluate IL-6 gene expression, IL-6 (interleukin 6) level, TNF-α (tumor necrosis factor), CRP (C-reactive protein), Cp (ceruloplasmin). Early administration of enrofloxacin resulted in an increase in IL-6 gene expression in the blood of 7-day-old turkeys, but no increase in serum IL-6 levels was found. Interestingly, in older, 56-day-old turkeys, the expression of the IL-6 gene was reduced, but there were no changes in the level of IL-6 in the blood serum of these birds. The study shows that early administration of enrofloxacin reduced the level of CRP in the blood serum of 7-day-old turkeys, but no similar changes were observed in older 56-day-old birds. A decrease in CRP in the blood serum of 7-day-old birds was also observed as a result of feeding the birds with a diet supplemented with the coccidiostat monensin. Early administration of enrofloxacin or doxycycline had no effect on serum TNF-α levels in the blood serum of 7-day-old turkeys, but a decrease in serum TNF-α levels was noted on day 56. There was no effect of the applied experimental treatments on the level of Cp. In conclusion, feeding turkeys with a diet supplemented with monensin or early application of enrofloxacin or doxycycline reduces the inflammatory response in the birds.
This work was supported by the National Science Centre in Poland, Grant No. 2020/39/B/NZ9/00765.
How to cite
Ł. Szymański, R. Smagieł, E. Cholewińska, K. Ognik, K. Kozłowski, J. Jankowski, 2023. Effect of feeding diet containing coccidiostat and administration of antibiotics to turkeys in the first days after hatching on blood inflammatory indicators. In: 2nd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL2.A029