Volume: 2, 2023
2nd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: P010
DOI: https://doi.org/10.24326/ICDSUPL2.P010
Published online: 19 April 2023
ICDSUPL, 2, P010 (2023)
The controlling of chemical composition of scCO2-extracts for pharmaceutical applications
Marcin Gruba1*, Katarzyna Tyśkiewicz1, Krystyna Skalicka-Woźniak2
1 Supercritical Extraction Research Group, Łukasiewicz Research Network – New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13a, 24-110 Puławy, Poland
2 Department of Natural Products Chemistry, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
* Corresponding author: marcin.gruba@ins.lukasiewicz.gov.pl
Abstract
The European Food Safety Authority (EFSA) announces that medicinal plants may contain naturally occurring substances with a potential risk to human health when used in food and dietary supplements. In addition, such plants grown in a traditional way may contain pesticide residues and heavy metals. The control of raw materials and their products is therefore a very important stage in the development of a technology for the production of plant extracts for pharmaceutical applications using supercritical CO2 extraction. For the project four plants from the EFSA list were selected, the extracts of which are used in dietary supplements: Goldenseal (Hydrastis canadensis L), Fenugreek (Trigonella foenum-graecum L), Moringa (Moringa oleifera L.), and Stinging nettle (Urtica dioica L.). They contain various substances e.g. berberine, trigonelline and a number of polyphenols. The plants were grown in a controlled environment on vertical farms that use energy from LED lamps. The growth of these crops is not dependent on the weather and climatic zone. As an important element of the quality control, a QuEChERS method for the determination of pesticide residues in raw materials and plant products using the LC-MS/MS technique has been developed. The applied approach will allow to define the procedures for the production technology of scCO2-extracts for pharmaceutical applications from the moment of plant growth to the preparation of a standardized extract with a specific content of active substances.
How to cite
M. Gruba, K. Tyśkiewicz, K. Skalicka-Woźniak, 2023. The controlling of chemical composition of scCO2-extracts for pharmaceutical applications. In: 2nd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL2.P010