Volume: 3, 2024
3rd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: A016
DOI: https://doi.org/10.24326/ICDSUPL3.A016
Published online: 24 April 2024
ICDSUPL, 3, A016 (2024)
Summary of therapeutic substances affecting AMDV-infected American mink
Marcin Kondracki1*, Andrzej Jakubczak1
1 Institute of Biological Basis of Animal Production, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
* Corresponding author: marcin.kondracki@up.lublin.pl
Abstract
Aleutian mink disease virus (AMDV), belonging to the Parvoviridae family and classified as Amdoparvovirus species, poses a serious threat to the health and welfare of farmed minks. The disease caused by this virus presents significant challenges for breeders and experts in the field of farming. Unfortunately, despite numerous attempts, an effective therapy or vaccine against AMDV has not yet been developed. This lack of effective measures hinders the fight against the disease, negatively impacting the health of animals and the economic situation of breeders. The aim of the study was to examine how selected preparations affect the biometric and physiological parameters of American minks that are persistently infected with the AMDV virus. In the study, 24 different substances were applied, including various groups of active substances. Based on the qPCR analysis results from samples (B0 and B1) for each animal, 7 preparations (Amantix, CellCept, Isoprinosine, Methotrexate-ebewe, Methylprednisolone, Moilec, Pepthym x thymus, Vaciclor) that met the initial requirements were identified. These preparations belong to the groups: antiviral preparations, immunosuppressive agents, immunostimulants, steroids. Verification of the results allowed to assess the potential for these substances. Particularly interesting appears Vaciclor, containing valacyclovir, which is an effective agent in reducing the risk of cytomegalovirus transmission in pregnant women with infection. The treatment contributes to reducing infections in newborns and reducing cases of pregnancy termination due to serious fetal abnormalities. Valacyclovir is characterized by a low risk of adverse effects, making it a promising option in infection prevention. Studies have shown that it also has a beneficial effect on minks infected with AMDV, and its known impact on pregnancy allows for broader studies on pregnant minks, potentially increasing fetal survival rates in mothers with AMDV. The results obtained from the conducted study may contribute to deepening our knowledge of defense mechanisms and therapies for diseases of animal origin, using the example of the AMDV virus. Viral diseases in animals are a significant problem from both ethical and economic perspectives. Therefore, research into better understanding the etiology of the AMDV virus and its impact on animal organisms, through the development of effective therapies, is crucial for animal health and welfare.
Keywords: mink, AMDV, therapeutic, virus
How to cite
M. Kondracki, A. Jakubczak, 2024. Summary of therapeutic substances affecting AMDV-infected American mink. In: 3rd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL3.A016