Volume: 3, 2024
3rd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: B004
DOI: https://doi.org/10.24326/ICDSUPL3.B004
Published online: 24 April 2024
ICDSUPL, 3, B004 (2024)
Catalytic effect of levodopa on the electroreduction of Zn2+ ions
Angelika Woś1*, Jolanta Nieszporek1
1 Department of Analytical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie Skłodowska University in Lublin, Marii Skłodowskiej-Curie 3, 20-031 Lublin, Poland
* Corresponding author: angelikawos29@gmail.com
Abstract
In the presence of even small amounts of electrochemically inactive organic compounds, the speed of electrode processes may change significantly. An example is the adsorption of levodopa on a mercury electrode, which results in catalyzing the electroreduction of Zn2+ ions. The obtained results can be successfully used as a model of biological systems helpful in explaining the pharmacological effects of drugs. The μAutolab electrochemical analyzer from Eco Chemie with a system of three electrodes was used for the research: mercury electrode as a working electrode, a silver chloride electrode as a reference electrode and a platinum wire as an auxiliary electrode. SWV and CV voltammetry, DC polarography and electrochemical impedance spectroscopy EIS were used. Changes in the position of the differential capacitance curves recorded in levodopa solutions in relation to the curve corresponding to NaClO4 indicate the adsorption of the drug on the surface of the mercury electrode. The measurements performed in Zn2+ solutions in NaClO4 (reference solution) and in the presence of levodopa indicated: – a clear increase in the height of SWV peak currents in the presence of levodopa compared to the reference solution, – reduction of the difference between the anodic and cathodic peak potential values on CV voltammograms, –reduction in the value of activation resistance associated with the electrode reaction in the presence of levodopa compared to the values corresponding to the reference solution (EIS), – increase in the electroreduction rate constants of Zn2+ ions determined for solutions containing the drug. Based on the collected results, the adsorption of levodopa on mercury in the analyzed systems was demonstrated, and, consequently, the formation of an active Zn2+ – levodopa complex on the electrode surface. This complex facilitates charge exchange between the electrode and the depolarizer and, as a result, accelerates the electroreduction of zinc ions on the mercury electrode. The catalysis of the process increases with increasing drug concentration.
Keywords: electroreduction, kinetics, catalysis, Zn2+, levodopa
How to cite
A. Woś, J. Nieszporek, 2024. Catalytic effect of levodopa on the electroreduction of Zn2+ ions. In: 3rd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL3.B004