Volume: 3, 2024
3rd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: H015
DOI: https://doi.org/10.24326/ICDSUPL3.H015
Published online: 24 April 2024
ICDSUPL, 3, H015 (2024)
The role of iron in the course of neurodegenerative disorders
Wojciech Białowąs1*, Weronika Zielińska1, Patrycja Białowąs2, Daria Stefaniak1, Michał Chrol1
1 Faculty of Medicine, Medical University of Lublin, Racławickie 1, 20-059 Lublin, Poland
2 Andrzej Frycz Modrzewski Cracow University, Gustawa Herlinga-Grudzińskiego 1, 30-705 Cracow, Poland
* Corresponding author: woj.bialowas@gmail.com
Abstract
Neurodegeneration with brain iron accumulation (NBIA) encompasses a spectrum of disorders marked by excessive iron deposition in the brain, predominantly within subcortical nuclei. While primarily presenting as neurological conditions, certain NBIA syndromes may also exhibit systemic manifestations. Most NBIA syndromes follow an autosomal recessive inheritance pattern, with symptom onset varying across ages, often prompting suspicion upon detecting hypointense changes in subcortical nuclei during brain MRI scans. Initially termed Hallervorden-Spatz disease, NBIA syndromes now encompass at least 10 classifications. Beyond NBIA, other neurodegenerative disorders may involve brain iron accumulation. Advancements in diagnostics and genetic testing enable the identification of distinct NBIA types, including PKAN, PLAN, MPAN, KRD, FAHN, aceruloplasminemia, neuroferritinopathy, Woodhouse-Sakati syndrome, and SENDA. Each syndrome exhibits characteristic clinical and neuroimaging features. Treatment primarily focuses on symptom management, although investigations into causative therapies, such as iron chelation and symptomatic interventions, are ongoing. In summary, comprehending the diverse NBIA syndromes, along with their clinical features, diagnostic modalities, and therapeutic strategies, is pivotal for effectively addressing these rare neurodegenerative disorders. The objective of this study was to review existing literature on the role of iron in the pathogenesis of neurodegenerative diseases, considering both its deficiency and excess states.
Keywords: neurodegeneration, iron accumulation, neuroferritinopathy, aceruloplasminemia, MRI
How to cite
W. Białowąs, W. Zielińska, P. Białowąs, D. Stefaniak, M. Chrol, 2024. The role of iron in the course of neurodegenerative disorders. In: 3rd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL3.H015