Volume: 4, 2025
4th International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: H025
DOI: https://doi.org/10.24326/ICDSUPL4.H025
Published online: 9 April 2025
ICDSUPL, 4, H025 (2025)
Postbiotics and their role in preventing Inflammatory Bowel Diseases
Kinga Zdybel1*, Angelika Śliwka1, Adam Waśko1
1 Department of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland
* Corresponding author: kinga.zdybel@up.lublin.pl
Abstract
Inflammatory bowel diseases (IBD) are classified civilization diseases, as their prevalence is increasing worldwide each year. The most commonly diagnosed clinical types of IBD are ulcerative colitis (UC) and Crohn’s disease (CD). The etiology and pathogenesis of IBD have not yet been fully explained. However, they thought to be related to unknown environmental factors, genetic susceptibility, impaired gut microbiota, impaired gut barrier function, and abnormal immune response. Many studies indicate that IBD is associated with gut dysbiosis, manifested by reduced numbers of beneficial microorganisms and excessive proliferation of pathogenic bacteria in the gut microbiome. Currently, live probiotic strains used to modulate intestinal microbiota or strengthen the intestinal barrier. However, there are still concerns about the safety of using live bacteria, especially in newborns and sensitive people. There is also a lack of sufficient studies assessing the viability of microorganisms once they have entered the intestine. These concerns have prompted researchers to seek alternative solutions, such as inactivated bacteria. Postbiotics are defined as preparations containing non-living microorganisms and/or their components that provide health benefits to the host. The most commonly used method for obtaining them is the inactivation of probiotic microorganisms through heat treatment. Postbiotics have a broad spectrum of biological activity, including anti-inflammatory, antioxidant, immunomodulatory, and inhibiting abnormal cell proliferation. The effectiveness of postbiotics relies on microbiological metabolites, proteins, organic acids, cell wall components, or other complex molecules produced during probiotic fermentation. Postbiotics have similar mechanisms of action to probiotics, while being storage stable and biologically safe due to their inactive form, making them a good alternative to probiotics. The aim of this review is to present the possibilities of using postbiotics in the prevention of inflammatory bowel diseases.
Keywords: postbiotics, non-live bacteria, inflammatory bowel disease, prevention, gut microbiota
How to cite
K. Zdybel, A. Śliwka, A. Waśko, 2025. Postbiotics and their role in preventing Inflammatory Bowel Diseases. In: 4th International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL4.H025