Volume: 1, 2022
1st International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: A018
DOI: https://doi.org/10.24326/ICDSUPL1.A018
Published online: 26 April 2022
ICDSUPL, 1, A018 (2022)
Virus evolution on the example of AMDV
Marcin Kondracki1*
1Institute of Biological Basis of Animal Production, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
* Corresponding author: marcin.kondracki@up.lublin.pl
Abstract
The Aleutian Disease virus is a representative of the genus Amdovirus of the Parvoviridae family. AMDV causes chronic and incurable Aleutian mink disease (Neovison vison). As a virus with a simple structure, it is difficult to fight, and thus there are no effective methods of treating this disease. The widespread occurrence and simple structure favor the development and mutation of the virus, especially in breeding conditions. There is currently no effective vaccine against AMDV. Understanding the development and evolution of viruses is an extremely important issue, especially now, as the SARS-COV-2 (COVID) virus has shown, they pose a pandemic threat. Additionally, Aleutian disease poses serious problems for American mink farmers (Neovison vison), such as its variability and resistance to disinfectants, and therefore poses a great challenge for farmers. By closely controlling the movement of animals, it is possible to track the spread of virus variants and their origin, also facilitating the development of phylogenetic trees. AMDV virus causes a disease of various course, which can take the form of persistent asymptomatic infections, transient infections, subclinical infections, to progressive infections, often fatal. Interactions between strains on each other are known, for example, an infected mink with one of the subclinical variants is not susceptible to infection with another virulent strain. The summary of the characteristics of the variants in this work shows the extensive mutation capacity of the virus even for such a simple virus as AMD. The inclusion of molecular methods based on bioinformatics analyzes in the routine diagnosis of AMDV can contribute to the elimination of the virus from farms, not only through early and sensitive detection of the pathogen in biological material from animals, but also by monitoring the effectiveness of disinfection activities, or identifying and closing viral circulation. The aim of the work was to create a phylogenetic tree that will allow to understand the mechanisms driving the evolution of viruses on the example of AMDV.
How to cite
M. Kondracki, 2022. Virus evolution on the example of AMDV. In: 1st International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL1/A018