ICDSUPL2-A006

Volume: 2, 2023
2^nd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT

Abstract number: A006

DOI: https://doi.org/10.24326/ICDSUPL2.A006

Published online: 19 April 2023

ICDSUPL, 2, A006 (2023)

Bovine colostrum is enriched in innate immune responses regulating proteins and exerts mucosal immunomodulatory activity in calf FMT-transplanted mice

Ramune Grigaleviciute¹*, Rita Planciuniene², Rolandas Stankevicius³, Vilma Zigmantaite¹, Audrius Kucinskas¹, Paulius Matusevicius³, Povilas Kavaliauskas^1,4,5

¹ Biological Research Center, Department of Animal Nutrition, Lithuanian University of Health Sciences, Tilzes str. 18, LT47181, Kaunas, Lithuania

² Institute of Microbiology and Virology, Lithuanian University of Health Sciences, Eiveniu str. 4, LT50161, Kaunas, Lithuania

³ Department of Animal Nutrition, Lithuanian University of Health Sciences, Tilzes str. 18, LT47181, Kaunas, Lithuania

⁴ Joan and Sanford I. Weill Department of Medicine, Weill Cornell University, 1300 York Avenue, NY 1109, New York, United States

⁵ Department of Microbiology and Immunology, University of Maryland Baltimore School of Medicine, Institute of Infectious Diseases and Pathogenic Microbiology, Prienai, Lithuania

^{* Corresponding author: ramune.grigaleviciute@lsmuni.lt}

Abstract

Bovine colostrum (BC) is the first milk produced by lactating cows after parturition and contains wide range nutrients. Recent studies have shown that BC is enriched in proteins that regulate innate immune responses although detailed composition or secretion kinetics are not well understood. Furthermore, BC contains a variety of immunoglobulins, growth factors, and antimicrobial peptides that can interact with the gut microbiota and influence its composition and function. The molecular mechanism that governs the BC-induced mucosal immunomodulation remains largely unknown. A detailed understanding of these mechanisms is crucial to develop a novel BC-based therapeutics. In this study, we use a molecular and proteomic approaches to characterize the BC-induced immunomodulatory activity in vitro and in vivo. Using this comprehensive approach, we identified major BC proteins involved in innate immune responses and demonstrated the immunomodulatory activity using calf FMT transplanted C57BL/6 mice model. These results will provide a foundation for further development of BC-derived and host-directed therapeutics.

How to cite

R. Grigaleviciute, R. Planciuniene, R. Stankevicius, V. Zigmantaite, A. Kucinskas, P. Matusevicius, P. Kavaliauskas, 2023. Bovine colostrum is enriched in innate immune responses regulating proteins and exerts mucosal immunomodulatory activity in calf FMT-transplanted mice. In: 2nd International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL2.A006