Volume: 5, 2026
5th International PhD Students’ Conference at the University of Life Sciences in Lublin, Poland:
ENVIRONMENT – PLANT – ANIMAL – PRODUCT
Abstract number: H012
DOI: https://doi.org/10.24326/ICDSUPL5.H012
Published online: 22 April 2026
From electrochemistry to therapy: novel heterocyclic compounds in the fight against colorectal cancer
Gabriela Machura*1, Sylwia Smarzewska2, Mateusz Kciuk3 and Mariusz Mojzych4
1 Department of Inorganic and Analytical Chemistry, University of Lodz, BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Lodz, Poland
2 Department of Inorganic and Analytical Chemistry, University of Lodz, 12 Tamka St., 91-403 Lodz, Poland
3 Department of Molecular Biotechnology and Genetics, University of Lodz, 12/16 Banach St., 90-237 Lodz, Poland
4 The Mazovian Academy in Płock, 2 Dąbrowski Sq., 09-402 Płock, Poland
Corresponding author: gabriela.machura@edu.uni.lodz.pl
Colorectal cancer is among the most frequently diagnosed malignant neoplasms worldwide and remains one of the leading causes of cancer-related mortality. Despite advances in diagnostics and therapy, the effectiveness of treatment for advanced stages of the disease is still limited, mainly due to the development of drug resistance and adverse side effects associated with currently used chemotherapeutics. Therefore, the search for new molecules with selective anticancer activity, together with the elucidation of their molecular mechanisms of action, constitutes an important direction in contemporary research focused on novel therapeutic strategies. Compounds containing fused heterocyclic systems with pyrazole, tetrazole, and triazine rings attract particular attention, as their rigid and flat structure allows them to effectively interact with key cellular biomolecules. Understanding the mode of interaction between such molecules and genetic material is especially important, as DNA damage represents one of the fundamental mechanisms leading to the inhibition of cancer cell proliferation and the induction of cell death.
The aim of this study was to characterize the electrochemical properties of selected compounds from a new series of sulfonamide derivatives of pyrazole-tetrazole-triazine systems, as well as to evaluate their ability to interact with double-stranded DNA. The obtained results demonstrate the ability of the investigated derivatives to directly interact with DNA, which may constitute one of the mechanisms underlying their anticancer activity. Thus, electrochemical studies provide valuable insights supporting the further development of this class of compounds as potential candidates for novel anticancer drugs.
Keywords: anticancer drugs; DNA interaction; electrochemistry; health; therapy
How to cite
Machura G., Smarzewska S., Kciuk M., Mojzych M., 2026. From electrochemistry to therapy: novel heterocyclic compounds in the fight against colorectal cancer. In: 5th International PhD Students’ Conference at the University of Life Sciences in Lublin, Poland: Environment – Plant – Animal – Product. https://doi.org/10.24326/ICDSUPL5.H012